Fat turns from diabetes foe to potential treatment
A new weapon in the war against type 2 diabetes is coming in an unexpected form: fat. Researchers have discovered a new class of potentially therapeutic lipids, called fatty-acid esters of hydroxy fatty acids (FAHFAs). These lipids are found at lower levels in people with insulin resistance, a risk factor for type 2 diabetes, compared with those who don’t have the condition. Administering FAHFAs to diabetic mice improved their glucose metabolism and insulin secretion, opening a surprising avenue for the development of novel medications for the disease.