How Type 2 Diabetes Develops In The Body | cure diabetes
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Obese people with type two diabetes are more than twice as likely to develop liver cancer, scientists have found.
A new study found that a high body mass index (BMI), increased waist circumference and type two diabetes increased the risk of liver cancer by 2.61 times.
And that risk rose with increases in BMI.
Researchers found an eight per cent risk increase for every five centimetres on someone’s waistline.
For every five kilogramme per metres squared increase in BMI, there was a 38 and 25 per cent increase in the risk for liver cancer in men and women, respectively.
Author Dr Peter Campbell, strategic director of digestive system cancer research at the American Cancer Society, said: ‘Liver cancer rates have approximately tripled in the United States since the mid-1970s and the prognosis for patients diagnosed with this type of cancer is especially grim.’
The NHS said although liver cancer is relatively uncommon in the UK over the past few decades, rates have risen considerably, possibly as a result of increased levels of alcohol consumption and obesity.
Dr Campbell and colleagues pooled data from 1.57 million adults enrolled in 14 different US-based studies.
Before beginning the study, participants completed questionnaires related to their height, weight, alcohol intake, tobacco use, and other factors potentially related to cancer risk.
None of them had cancer at enrollment.
Type 2 diabetes was diagnosed in 6.5 per cent of the study participants, and over time, 2,162 of the participants developed liver cancer.
The researchers compared the rates of liver cancer among participants with and without obesity and diabetes to determine the relative risks of liver cancer.
Dr Campbell said: ‘We found that each of these three factors was associated, robustly, with liver cancer risk. All three relate to metabolic dysfunction.
‘This adds substantial support to liver cancer being on the list of obesity-associated cancers.’
‘This is yet another reason to maintain a body weight in the ‘normal’ range for your height.’
He added that the findings are also consistent with other data indicating that obesity and diabetes might be playing a role in the rapid increase in liver cancer in recent decades.
Dr Campbell added: ‘Liver cancer isn’t simply related to excess alcohol intake and viral hepatitis infection.
‘The lifetime risk for liver cancer in the United States is about one per cent; approximately eight adults per 100,000 will develop liver cancer in a given year.
‘For adults with type two diabetes, their risk of developing liver cancer is more than doubled relative to those who do not have type two diabetes, according to this study.’
Co-author Dr Katherine A. McGlynn, a senior investigator in the Metabolic Epidemiology Branch at the National Cancer Institute, said: ‘From a public health perspective, these results are very important because obesity and diabetes, unfortunately, are common conditions in the population.
‘While some other well-described risk factors, such as hepatitis B virus or hepatitis C virus, are associated with increased risks of liver cancer, these factors are much less common than are obesity and diabetes.’
The study was published in Cancer Research.
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