HomeVideoMitra Mosharraf | HTD Biosystems | USA | Drug Delivery 2015 | Conference Series LLC

Mitra Mosharraf | HTD Biosystems | USA | Drug Delivery 2015 | Conference Series LLC

World Drug Delivery Summit August 17-19, 2015 Houston, Texas, USA

Scientific Talk On: Strategies to improve dissolution rate of lyophilized high dose protein formulations

Click here for Abstract and Biography: http://drugdelivery.pharmaceuticalconferences.com/speaker/2015/mitra-mosharraf-htd-biosystems-inc-usa

Mosharraf received her M. Sc. in Pharmacy and her Ph.D. in Pharmaceutical Sciences from Uppsala University. Prior to joining HTD Biosystems as the chief scientific officer, she held different positions at Pharmacia and Pfizer, where she was actively involved in the formulation development of protein drugs. She has several scientific publications in peer-reviewed journals in the areas of protein formulation, solubility and dissolution rate of sparingly soluble drugs and a patent on manufacturing crystals of growth hormone. She has also been an invited lecturer in Pharmaceutics at the Department of Pharmacy, Uppsala University on a regular basis.

There is an increasing interest in formulation development of lyophilized proteins and monoclonal antibodies at high concentration. Development of high dose protein formulations, is often associated with challenges such as slow dissolution of the lyophilized cake, poor syringeability, aggregation and thus poor stability after reconstitution. The latter becomes a major concern especially for the development of multi-dose formulations that may require several days of post-reconstitution stability, especially considering the protein preservative interactions. In this presentation the important parameters for improving dissolution of lyophilized protein cakes are discussed. Especial attention is paid towards dissolution of high dose protein formulations in dual chamber syringes, and strategies to improve dissolution rate of the lyophilized cakes in general.

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