Personalized Medicine - Atul Butte, Stanford University
Translating a Trillion Points of Data into Therapies, Diagnostics, and New Insights into Disease
Atul Butte, Stanford University
There is an urgent need to translate genome-era discoveries into clinical utility, but the difficulties in making bench-to-bedside translations have been well described. The nascent field of translational bioinformatics may help. Dr. Butte’s lab at Stanford builds and applies tools that convert molecular, clinical, and epidemiological data — measured by researchers and clinicians over the past decade — into diagnostics, therapeutics, and new insights into disease. Dr. Butte, a bioinformatician and pediatric endocrinologist, will highlight his lab’s work on using publicly-available molecular measurements to find new uses for drugs including drug repositioning for inflammatory bowel disease, discovering new treatable inflammatory mechanisms of disease in type 2 diabetes, and the evaluation of patients presenting with whole genomes sequenced.
Background Review Article:
Butte AJ. Translational bioinformatics: coming of age. J Am Med Inform Assoc. 2008 Nov-Dec;15(6):709-14. doi: 10.1197/jamia.M2824. Epub 2008 Aug 28.