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Research finds genetic explanation for beta cell decline in type 2 diabetes



Research finds genetic explanation for beta cell decline in type 2 diabetes
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Research finds genetic explanation for beta cell decline in type 2 diabetes

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A new study shows that beta cells stop replicating when missing a receptor on their surface through which key genetic changes for beta cell production happen.The findings add more details to our understanding of progressive beta cell function decay in type 2 diabetes. They could also give rise to treatments artificially stimulating compounds to resume the beta cell growth cycle.As insulin resistance progresses in the early onset of type 2 diabetes, the body initially tries to compensate by ramping up the production of beta cells. After a while, though, it eventually comes to a standstill, and researchers have long tried to understand why that is. “Very often many of the beta cells that begin the cell cycle don’t complete it because the regulatory signals aren’t appropriate,” said senior investigator Rohit Kulkarni, Harvard Medical School. “The cells choose to die because that’s an easier route than completing the cell cycle.”

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type 2 diabetes, type 1 diabetes

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