The Brain-Glucose Connection: Claude Bernard Revisited
Wednesday, November 14, 2012
Robert Sherwin, M.D.
C.N.H. Long Professor of Medicine (Endocrinology)
Director, Diabetes Endocrinology Research Center at Yale University School of Medicine
Section Chief, Endocrinology
Director, Yale Center for Clinical Investigation
Dr. Sherwin revisits the control center for glucose homeostasis within the brain, as proposed one and a half centuries ago. Fast forward to present day for an intellectual discussion on the ventromedial hypothalamus’ role in glucose counterregulation. This mechanism paints the picture of hypoglycemia-induced adaptations in brain fuel metabolism as it coalesces into homeostasis across the blood-brain barrier. Finally, he will go back to Claude Bernard’s original idea and present data suggesting insulin in the brain may contribute to type 2 diabetes, eating behavior and cognitive function.