The “on/off” switch of the immune system - Role of PTP1B in the regulation of the immune system
Obesity is associated with insulin resistance, type 2 diabetes, cardiovascular disease, cancer and many other devastating diseases. Obesity is also a state of chronic inflammation and, as such, the cells in our immune system become overactive.
Professor Mirela Delibegovic is studying proteins crucial in the on/off switches in our immune cells, called tyrosine phosphatases. Using the latest DNA sequencing technology, this research will allow development of new therapies to treat diseases such as type 2 diabetes, heart disease, cancer and inflammation.