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Type 2 Diabetes: A Complicated Disease

It has become clear in the last decade that diabetes is a very complicated disease with multiple etiologic disturbances. Insulin resistance in the liver and muscle, and beta-cell dysfunction are only the most well-known of the several abnormalities that occur in type 2 diabetes patients.Ralph DeFronzo, MD, Chief of the Diabetes Division at the University of Texas Health Science Center in San Antonio discusses the pathophysiology of T2DM and what we have learned to combat it.


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