What Causes High Serum Creatinine Level in Diabetics
Creatinine is a common measurement for kidney function. Creatinine, as well as uric acid and other wastes, are normally excreted through the kidneys. For chronic kidney disease patients, at initial time, small amount of renal intrinsic cells are damaged, the healthy nephrons work in a decompensated way so as to maintain a normal serum creatinine level. Only when more than 50 percent of kidney units are impaired will serum creatinine increase. Therefore, high serum creatinine usually indicates severe kidney diseases.
For diabetics, kidney disease is a result of glomerular capillary damage caused by high blood sugar. Other risk factors for diabetic kidney disease(diabetic nephropathy) include high blood pressure, smoking and heredity susceptibility. Due to deposition of exellular matrix and thickening mesangial basement membrane, more and more renal intrinsic cells are damaged, causing continuous kidney function decline.
Throughout the deteriorating process, increasing protein in urine is a typical symptom, which is usually accompanied by swelling(edema). What comes along kidneys’ insufficiency to filtrate blood is the increasing serum creatinine, blood urea nitrogen and accumulation of other wastes products. Overall metabolism turned into disorder and multiple complications appear, including:
1. Water metabolism disorder, causing symptoms such as polyuria, nocturia, thirst, mucosal dryness, fatigue, etc; or systemic edema, high blood pressure, pulmonary edema and heart failure.
2. Erythrocyte imbalance
Normal kidneys are effective in regulating erythrocyte balance. When kidneys are severely impaired, erythrocyte imbalance will present, causing hyperkalemia or hypokalemia, hypernatremia or hyponatremia.
3. Metabolic acidosis, causing symptoms such as deep breathing, anorexia, abdominal pain, nausea, vomiting, weakness, headache, irritability or even coma.
4. Endocrine dysfunction, such as thyroid dysfunction, sexual dysfunction, growth retardation and so on.
5. Metabolic disorders, including carbohydrate metabolism disorder, lipid metabolic disorder, protein and amino acid metabolic disorder, etc.
The above symptoms are caused by severe kidney injury. For diabetics, there can be accompanied complications caused by longstanding diabetes, such as diabetic retinopathy, cardiovascular diseases, diabetic peripheral lesions, diabetic neuropathy and so on. Those combined situations can be life-threatening to diabetics.
At this time, dialysis is helpful in alleviating the complications and discomforts by artificially removing toxins. However, as dialysis can not repair the damaged kidneys, patients are advised to take positive measures to repair the damaged kidneys promptly.
Source by tcmremedy